CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast

摘要

Study of the essential roles of CDK in initiation of DNA replication in fission yeast indicates that CDK phosphorylates Sld3 and Drc1/Sld2 and promotes their interactions with Cut5, which are required for origin loading of Cut5. Thus CDK regulates assembly of replication factors onto origins by promoting ternary Sld3–Cut5–Drc1 complex formation.